Congratulations to CPVB COBRE investigator Corey E. Ventetuolo, MD, MS (Assistant Professor of Medicine and Health Services, Policy, and Practice, Brown University), who has been awarded $3.7M R01 from the National Heart, Lung, And Blood Institute for proposed research on “Effects of DHEA in Pulmonary Hypertension (DIPH)”. This grant will include the first clinical trial of an endogenous sex hormone, dehydroepiandrosterone, in pulmonary arterial hypertension and will provide mechanistic insight into sexual dimorphism in cardiopulmonary phenotypes including right ventricular failure.
CPVB COBRE investigator Alan Morrison, MD, PhD Assistant Professor of Medicine, Warren Alpert Medical School Brown University, was awarded an R01 titled “Development of Rac-Targeted Therapeutic Strategy for Treatment of Calcific Atherosclerosis”. In July 2016 Dr. Morrison received a 12 month pilot project from the CPVB COBRE and graduated to COBRE investigator June 2017. Dr. Morrison’s R01 study will define the role of macrophage Rac-dependent signaling during inflammatory calcification of atherosclerotic plaque.
Dr. Alan Morrison has been appointed as a Junior Investigator with the CPVB COBRE at the Ocean State Research Institute. Morrison is currently an Assistant Professor of Medicine (Cardiology) at Warren Alpert Medical School Brown University. He completed his residency and fellowship at Yale New Haven Hospital. His project is titled “Statins Influence Cardiovascular Outcomes by Modulation of Atherosclerotic Plaque Calcium Density”. Dr. Morrison’s laboratory focuses on mechanisms of immune-mediate vascular remodeling by studying the macrophage-directed the biologic processes of arteriogenesis, atherosclerosis and atherosclerotic calcification, and pulmonary arterial hypertension. The overarching goal of the research in his lab is to define macrophage-dependent signaling mechanisms that modulate these processes in order to identify novel targets for the development of new inhibitory strategies that might one day be used in the clinic.
Dr. Qing Lu, Associate Professor of Medicine (Research), Warren Alpert Medical School Brown University, has graduated from CPVB COBRE junior investigator to independent PI. Since the CPVB COBRE’s commencement in September 2013, Dr. Lu and her team have worked diligently on her project “Role of Adenosine in Cigarette Smoke-Induced Lung endothelial Injury”. In July 2016, Dr. Lu received R01 funding for her project “HDAC6 regulates cigarette smoke-induced endothelial barrier dysfunction and lung injury”. This study will provide innovative insights into the effect of cigarette smoke on lung endothelial barrier function. Establishment of the links among HDAC6, mitochondrial fission and mtDAMPs may result in new therapeutic approaches to cigarette smoke-induced vascular injury in the lung and potentially also in the systemic circulation.
Congratulations to Qing!
Dr. Debasree Banerjee was awarded a 12-month pilot project with the CPVB COBRE at the Ocean State Research Institute. She is an Instructor of Medicine at the Warren Alpert Medical School of Brown University, Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital, Providence, RI. Dr. Banerjee’s research focuses on investigating Chitinase 3 Like 1, an inflammatory biomarker in the cecalligation and puncture mouse model. Her pilot project is entitled “Characterizing Immunomodulation and Inflammation in Sepsis: The Role of Chitinase 3 Like 1”. Her academic and research objectives for the next three years are to establish funding for her research in the form of a mentored K award related to the immunomodulation in shock.
Dr. Alan Morrison was awarded a 12-month pilot project with the CPVB COBRE at the Ocean State Research Institute. Morrison is currently an Assistant Professor of Medicine at Warren Alpert Medical School of Brown University. He completed his residency and fellowship at Yale New Haven Hospital. His pilot project is entitled Therapeutic Targeting of IL-1β-Based Mechanisms in Calcific Aortic Valve Disease. Dr. Morrison’s long-term goal is to develop a successful independent research program with strong emphasis on using molecular imaging techniques to facilitate mechanistic studies in preclinical models of disease in order to identify critical modulators of pathology that may be viable targets for novel clinical strategies.
Dr. Hongwei Yao was awarded a 12-month pilot project with the CPVB COBRE at the Ocean State Research Institute. Yao is currently appointed as an Associate Professor of Molecular Biology, Cell Biology & Biochemistry (Research) at Warren Alpert Medical School of Brown University. He has more than 10 years research experience studying the pathogenesis and potential pharmacological interventions in chronic lung diseases using in vitro in cells including endothelial cells, in vivo in animals and ex vivo in human peripheral tissues. His pilot project is entitled Metabolic Dysregulation in Pulmonary Endothelial Dysfunction during Hyperoxic Lung Injury. The long-term goal of this study is to determine the molecular mechanisms of hyperoxic lung injury during the development of Bronchopulmonary Dysplasia (BPD), as well as to identify the potential targets for therapeutic management for this disease.
Dr. Jason Aliotta was awarded a 5-month pilot project with the CPVB COBRE at the Ocean State Research Institute. He is an Assistant Professor of Medicine at the Warren Alpert Medical School of Brown University, Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital, Providence, RI. Dr. Aliotta’s research focuses on the interaction between the pulmonary vasculature and bone marrow via circulating extracellular vesicles. His pilot project is entitled “The role of extracellular vesicles in the pathogenesis of pulmonary hypertension”. The long-term goal is to identity an alternative target for developing therapies for PAH.
Congratulations to Amanda Jamieson, PhD, featured on NBC 10 news for her research on e-cigarettes.
Dr. Won-Kyung Cho was awarded a 5 month pilot project with the CPVB COBRE at the Ocean State Research Institute. Cho is currently an Assistant Professor Medicine – Pulmonary at Warren Alpert Medical School of Brown University and an attending at the Providence VA Medical Center. Her pilot project is entitled Interleukin-13-mediated mechanisms of pulmonary vascular remodeling. Cho’s proposal provides an innovative concept of the possible interplay between inflammatory and metabolic processes, which would shed greater insights into the pathogenesis of PAH. The ultimate goal is to apply for independent funding for further development of this project including a possible clinical trial.
Ocean State Research Institute
Providence VA Medical Center
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Research reported in this website was supported by the National Institute of General Medical Science of the National Institutes of Health under grant number P20GM103652.