Sean F. Monaghan, MD, FACS

Sean F. Monaghan, M.D. awarded NIH R35 funding for “Improving Sepsis Care with Deep RNA Sequencing Data”

Sean F. Monaghan, M.D. was awarded NIH R35 funding for “Improving Sepsis Care with Deep RNA Sequencing Data” from the National Institute of General Medical Sciences. Dr. Monaghan is currently an Assistant Professor of Surgery at Brown University Warren Alpert Medical School and a member of the Division of Trauma and Surgical Critical Care and the Division of Surgical Research within the Department of Surgery. His research focuses on using RNA sequencing data and computational biology to understand RNA splicing in critically ill trauma and surgical patients. Dr. Monaghan has previously used acute respiratory distress syndrome (ARDS) as a model disease but now focuses on obtaining samples from patients with sepsis. It is hoped that this funding will promote past work (and related patents) and transition the findings to clinical relevant diagnostic tests and novel therapies for sepsis.

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Research Project Call for Applications

Cardiopulmonary Vascular Biology COBRE
Research Project Leader Award Program Funding Opportunity


We are inviting applications for a Research Project Leader at the CardioPulmonary Vascular Biology Center of Biomedical Research Excellence (CPVB COBRE). The vision of the CPVB COBRE is to advance the understanding of vascular diseases affecting the pulmonary and cardiovascular systems. CPVB COBRE has a multidisciplinary group of outstanding investigators who are using cutting edge tools to understand the pathobiology of vascular diseases.

Research Project Leader will gain access to the COBRE interdisciplinary cores which provide infrastructure, consultation, and additional support services to ensure the successful career development of the funded investigator. The three Cores include Administrative, Cell Isolation/Organ Function, and Respiration Core.


A Research Project Leader must hold a faculty appointment (or equivalent at research institutes) at a Rhode Island research institution, and eligible for employment at Ocean State Research Institute for the effort proposed on the application at the time of the award and can be either:

A junior investigator who does not have and has not previously been a PI on an external, independent, peer-reviewed research project grant (R01) or Program Project Grant (PPG) or PPG subproject, or equivalent award from either a Federal or non-Federal source, or

An established investigator who is making a significant change to their career goals by initiating new line(s) of research that is significantly different from their current investigative program. Established investigator is defined as an investigator who has current or prior external, independent, peer-reviewed research project grant (R01) or Program Project Grant (PPG) from either a Federal or equivalent award from a non-Federal source. The established investigator must demonstrate a record of research productivity that contributes to the CPVB COBRE strength and competitiveness. Senior, funded investigators who are not making a significant career change are not eligible.

Junior Investigators must have a mentor(s). Mentor(s) should be designated who are faculty (Associate Professor level or above) at an affiliated health care system or a degree-granting institution in Rhode Island. Mentor(s) should be researchers in the field related to the proposed project and have experience and demonstrated success as research supervisors.

The Research Project Leader cannot hold funding from a COBRE project or another IDeA mechanism of support at the same time as CPVB COBRE funding.


Funding is available for one Research Project Leader to support from December 1, 2021- May 31, 2022 at $125,000 direct costs and June 1, 2022 – May 31, 2023 funding support of up to $184,000 direct costs.


The project period is 18 months.


October 11, 2021, midnight


Send inquiries regarding the CPVB COBRE Program to